Prior studies have pointed to the role of the bacterial protein LcrV as a critical element of plague virulence. LcrV acts a molecular “needle” to inject toxins into host cells, and it also suppresses the immune response through two mechanisms. First, it stimulates the host to release interleukin-10 (IL-10), which dampens the innate immune response. Second, it prevents the release of two pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). This immunosuppressive activity makes native LcrV a poor vaccine candidate, despite its immunogenicity. Senior author Olaf Schneewind led the two research teams at the University of Chicago, whose results were published online Jul 28 in Science and in the August issue of Infection and Immunity. Aug 19, 2005 (CIDRAP News) – Two research reports on plague were recently released, one describing the mechanism that the plague bacterium uses to evade the body’s immune system and the other describing a potential vaccine that was tested successfully in mice. Today, about 1,000 to 3,000 cases of plague (primarily bubonic) occur worldwide each year, including approximately a dozen in the western and southwestern United States. Although plague killed hundreds of millions of people in past pandemics, no human plague vaccine is currently licensed in the United States. Marketon MM, Depaolo RW, Debord KL, et al. Plague bacteria target immune cells during infection. Science 2005 (published online Jul 28) [Abstract] The bacterium Yersinia pestis causes different forms of plague, depending on the route of exposure. Bubonic plague, infamous as the “Black Death” of the Middle Ages, is transmitted by flea bites. The disease persists in its natural reservoir of wild animals, primarily rodents, passing to humans via fleas that first bite an infected animal. Inhalation of the bacteria causes pneumonic plague, a disease that is seen less often in nature but could develop if aerosolized plague bacteria were released in an act of bioterrorism. Mice were first infected with the modified plague strains and then sacrificed and their spleen tissues separated into specific cell populations. Staining with CCF2-A dye allowed visualization of cells injected with Yop-Bla, because only cells containing this engineered protein glowed blue. Despite the predominance of CD4 and CD8 cells in the spleen, the majority of cells targeted by the modified Y pestis were macrophages, neutrophils, and dendritic cells. This strategy, the authors wrote, allows the bacterium to “destroy cells with innate immune function that represent the first line of defense, thereby preventing adaptive responses and precipitating the fatal outcome of plague.” Finally, the authors tested the rV10 protein in a mouse immunization experiment. The protein elicited high titers of immunoglobulin G (mean, 112,500 by ELISA), which were comparable to those induced by native LcrV. Additionally, two intramuscular doses of rV10 (100 mcg each, with alhydrogel adjuvant) protected 100% of mice challenged with heavy doses of Y pestis. In the Infection and Immunity article, the researchers describe how they investigated modified LcrV proteins for three criteria of a successful vaccine: lack of IL-10 stimulation, preservation of pro-inflammatory cytokine secretion, and robust antigenicity. The authors deleted sequential 30-amino-acid portions of LcrV to create 12 candidate deletion proteins. Two of these, rV7 and vV10, failed to induce IL-10 secretion in mouse macrophages. Further testing showed that the rV10 peptide was not capable of significantly suppressing TNF-alpha secretion. Overheim KA, Depaolo RW, Debord KL, et al. LcrV plague vaccine with altered immunomodulatory properties. Infect Immun 2005 Aug;73(8):5152-9 [Abstract] The authors of the Science paper wanted to know exactly which immune cells are targeted by plague. The authors engineered a protein to identify the cell types injected with toxin by the plague bacterium. They created a piece of DNA containing genes for both Yersinia outer proteins (Yop) effectors and beta-lactamase (Bla). Yops are the toxins normally injected by plague into host cells; Bla is an enzyme that cuts a dye called CCF2-AM, making it fluoresce blue instead of green. The team inserted this piece of DNA into Y pestis strains. Both studies received support from the National Institute of Allergy and Infectious Diseases. Thus rV10, the authors explained, “satisfied our experimental criteria and displayed significant defects in immune suppression without reducing the protective properties of plague vaccines.” They conclude, “It appears that LcrV variants with reduced immune modulatory properties could be used as a human vaccine to generate protective immunity against plague.” Without prompt antibiotic treatment, the case-fatality rate of plague approaches 100%. A major reason for this high mortality is that the invading bacteria suppress the body’s immune response. The plague bacterium uses a system that injects toxins directly into host cells. Previous studies have indicated that Y pestis evades the immune system by resisting phagocytosis and suppressing the inflammatory response. See also: CIDRAP plague overview
May be time to end the Israel experimentSadly, Bruce Tractenberg, in his May 23 letter, and others of his ilk overlook the terrorist actions of Israel: shooting unarmed civilians, forced detentions, appropriation of property, assassination of politicians, destruction of infrastructure, the list of Israeli crimes goes on.But he does bring up a good point: Israel’s right to exist.Israel was created out of a collective European/American guilt over the Holocaust. It was the last gasp of colonial powers in an already largely post-colonial world.A nascent Israel then terrorized, rounded up, or otherwise routed the resisters and totally disenfranchised them of their property rights.The original terrorists in the Middle East? Jews. Doubt that? Look up the King David Hotel bombing or the Irgun policy. The reason Bruce Trachtenberg and other Zionists can get away with all of their wild claims about the inherent goodness of Israel and label any criticism as “anti-Semitic” is because of Americans’ lack of world knowledge.If someone came to the community where my family had lived for a thousand years, decided they liked it and stole it, forced us to live in tin shacks in a ghetto with limited access, limited building supplies, even limited calories (Israel has at times calculated and limited per capita caloric intake), I guess I’d probably be angry too.The so-called terrorism in the Middle East was entirely predictable, and it has been largely aided and abetted by the United States. But one man’s terrorist is another man’s freedom fighter. It may be time to end the experiment called Israel, and return the land to those who had owned it for centuries.James Van DijkSaratoga SpringsCuomo should make declawing cats illegalI urge Gov. Andrew Cuomo to sign into law the bill to make declawing of cats illegal in New York. New York stands for reason and compassion and should be the first in the nation to ban this cruel practice.It’s barbaric and inhumane to declaw a cat. People rationalize that it’s best for the cat. But anyone who genuinely loves and respects their feline friends would never declaw.As far as permitting this abusive practice to continue “as a last resort,” I say no. It’s too easy to bend the truth to suit an expedient owner. Animals should not be treated as disposable commodities.Stand up to the New York State Veterinary Medical Society and pass a law with teeth, claws and integrity. How a society treats its animal companions is telling.Rosemary Christoff DolanSchoharieNo U.S. interference in Venezuela’s affairsIn my May 2 letter, I stated incorrectly that the current president of Venezuela won “the 2018 election widely recognized worldwide as fairly conducted.” A leading candidate was blocked from participation and the election was highly flawed. I regret the error.Nevertheless I still believe the United States has no right to interfere in the internal affairs of Venezuela, topple the Venezuelan government or strangle the Venezuelan economy with devastating sanctions now in place.In late April, the Washington, D.C.-based Center for Economic and Policy Research published a report on the negative impacts of U.S. sanctions, which stated there “is no doubt that all of these sanctions since August 2017 have had severe impacts on human life and health.”The sanctions may have caused over 40,000 deaths in 2017-2018, and more than 300,000 people are at risk due to lack of access to medicines or treatment, including thousands who depend on antiretroviral treatments, dialysis treatments or who have cancer. The report said the sanctions “are a death sentence for tens of thousands of people who cannot leave the country to find medicines elsewhere.” Food imports declined from $11 billion in 2013 to $2.5 billion last year, intensifying hunger and malnutrition. The report said the sanctions imposed by the Trump Administration are illegal under the charter of the Organization of American States, international human rights law, and treaties signed by the United States.I favor a Venezuelan national referendum and fair elections without U.S. threats and sanctions. Tom EllisAlbany I always look forward to reading Sara Foss’ informative columns. But the one on June 4 was one that really hit home with me because of my experience one year ago with the palliative care system as stated in the Medicare Law.The New York Conference of Retired Americans in April passed a resolution addressing my issue about the present Medicare law on palliative care.I was the caregiver for my husband, who had Alzheimer’s and a blood disorder.Not wanting to discontinue his treatments, we opted for palliative care instead of hospice.When we wanted to go to our home in St. Lawrence County, where my husband could enjoy sitting on the deck overlooking the lake. Otherwise he was a prisoner in his own house. We were told we needed to be home-bound in Schenectady county to receive palliative care. Medicare states three reasons to leave your home: go to doctor appointments, go to church or to hair appointments.These restrictive and punitive Medicare rules need to be loosened or eliminated to be in accordance with the best practices for palliative care and provide the best care for each patient.It’s important to know the three reasons that are allowed for a patient to leave home while getting palliative care and to make changes for the quality of life of all.Mary PritchardSchenectady Categories: Letters to the Editor, OpinionNew Yorkers pay too much for educationIn the June 9 story about Johnston school budget issues, it’s implied the school board was somewhat irresponsible for keeping tax increases at reasonable levels.As noted, the levy increased by a total of 55 percent from 2003. Looking at additional statistics from the same time period, the Social Security Administration says the average salary has gone up close to 50 percent, while $100 then would be worth $138.88 today, less than a 34 percent increase. So salaries and the cost of living all fall in line with the Johnston increases (and the costs of the people actually paying the tax bills). So this seems very reasonable to me.The article pointed out Broadalbin’s 160 percent increase, which unless coupled with increased student enrollment is a prime example of extreme irresponsibility.And we hear so much talk about out-of-control college costs and increases. But when it comes to K-12, there is never enough money. Consider this, Burnt Hills spent $21,990 per K-12 student last year, according to the latest data. Compare to SUNY Geneseo, where full- time students pay $22,260 total, of which $13,214 covers room and board, items not covered at BHBL.People complain about the cost of college but in New York, it’s actually significantly cheaper than your local high school. Thank goodness for the tax cap.William FarmerBurnt HillsPalliative care rules need to be reformed Farm labor demands will hurt small farmsI see that farm workers are demanding overtime and the right to organize.I find this disingenuous, since the farmers that employ them are themselves working excessive hours and still operating at a loss, i.e. they aren’t paid anything.In chess, several moves are required for checkmate. On one hand, the federal government sets milk prices below the cost of production for most of the small and humane farms. They force agribusiness to go large and run crowded factory farms in order to make money and at the same time destroy any competition from local or family farms. Most farmers are independent to their own detriment and are mainly interested in farming, not politics. The checkmate move now comes from the labor required to run the farm.We are used to getting benefits at the expense of others. Some make the analogy that milk costs more than gasoline. However, l don’t need to buy 40 gallons of milk a week to survive. Most of us can afford to pay a fair price for milk and in so doing preserve family farms.Farm-family children are leaving the business. When their parents are driven out or quit, we are dead.As one said, “Unless you can raise your own meat and produce, don’t complain about farmers with your mouth full.”Bruce MartindaleCharltonNo, Trump is not a backer of Neo-NazisRegarding Michael Boehm’s June 6 letter, (Is this how you make America great again?), when has President Trump ever said there are good Neo-Nazis? The only instance that is mistakenly referred to are his comments having to do with the Charlottesville’s protest march of taking down Robert E. Lee’s statue. Yes, there were Neo-Nazis there, but there were also good, common folk protesting. So when President Trump said, “You also had people that were very fine people, on both sides,” he’s referring to the good, common folk. Trump specifically disavows the Neo-Nazis throughout the interview; the transcript can easily be found online. Mr. Boehm subtlety associates Trump as a Neo-Nazi, a point that can be further refuted. First, Trump was in Europe commemorating the D-Day invasion, which led to the defeat of the Nazis, something that a Nazi sympathizer would find difficult to participate in.Second, Trump is arguably the most pro-Jewish president we have ever had, having moved the U.S. embassy in Israel from Tel Aviv to Jerusalem, a move that no other president could muster the courage to do. MAGA.Mark BrockbankRotterdamNo driver’s licenses for illegal immigrantsHmmm, driver’s licenses to undocumented immigrants to “make it easier for them to get to work” huh?Well, that’s a fantastic solution on how to aid and abet illegal immigrantion. Just tell me why? They can get into our country, get hired and pay no taxes, but when they can’t get to work, we just give them licenses? Have we gone mad? This is the biggest bunch of lunacy I have seen in a long time. I know, some of you feel righteously sympathetic to those who raise the rates of everything in our country for yourselves and others, and you feel the need to help these folks.Instead of licenses, let’s give them paperwork. Good ol’ immigration paperwork that they fill out, wait however long the legal process works, and let them become legal citizens. Anything short of that, you might as well give the country away.Does anyone else see the door opening for them to get other documents once they secure a New York state driver’s license? It’s just mind blowing that our governor is even considering this. Oh wait, it’s votes for him. Now I get it. Brian BaldwinBurnt HillsMore from The Daily Gazette:EDITORIAL: Beware of voter intimidationEDITORIAL: Find a way to get family members into nursing homesEDITORIAL: Thruway tax unfair to working motoristsGov. Andrew Cuomo’s press conference for Sunday, Oct. 18EDITORIAL: Urgent: Today is the last day to complete the census
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Sales at Moriyama’s six fish joints called “IROM Inc.” have tanked 90 percent and he’s struggling to pay rent and salaries for some 100 staff. “What we need now is financial support to help us pay rents and compensate for business closures rather than future campaign on tourism,” Moriyama told Reuters.Some owners say the government’s subsidy of up to $55,000 for each firm to cover rents is insufficient, and that it could afford to do more to keep businesses open and free up cashflow. Last year, rents for all of Japan’s restaurants totalled $13 billion – less than the $16 billion going into tourism promotion.The government’s subsidy list includes items such as five-star sirloin Kobe beef steak, which costs some $37.20 for 100g, and top-quality Yubari melon that sells for more than $90 per 1.6-kg fruit.Agriculture ministry official, Satoru Nishio, said the subsidy, which also covers expensive mangoes, strawberries and tunas, was intended “to back farmers facing a decline in inbound tourists and exports.”The government subsidises half of the cost of buying the produce for e-commerce, take-away services and provision of school meals. For example, traders get up to $9.31 per 100g of wagyu beef and up to $22.34 per kilo of melons.Funds tied up in red tapeWhile a total of $190 billion in financing, loans, cash subsidies and other benefits have been set aside for small businesses, some analysts say struggling firms have been deprived of quick access to much-needed cash due to red tape.“A government financial agency should provide loans that can be allotted to rents to prevent cashflow from drying up,” said Kota Matsuda, a former lawmaker who now runs a chain of 30 restaurants including 22 Hawaiian-style restaurants called Eggs ‘n Things, employing about 600 workers.“It’s impossible to cover rents solely with subsidies,” said Matsuda, who has applied for funds but has been frustrated by the cumbersome process as he tries to meet cash needs of more than $650,000 for salaries and $372,370 for rents.Sales at his restaurants, which reopened fully last Saturday, declined by 90-95 percent year-on-year in April.IROM’s Moriyama, who applied for a couple of subsidies, said they were “far from enough” to make up for the losses.“I can’t foresee what will happen to my business.”Topics : As the coronavirus jolts Japan, the government’s huge stimulus package has come under fire from hard-hit restaurant owners for channelling funds for items like wagyu beef, melons and tourism rather than accelerating help for firms with burning cash needs.The restaurant industry’s struggles highlight a larger problem in Japan’s revival plan, which at US$2.2 trillion is the size of Italy’s economy but is still falling short of sufficient support to an important segment – small businesses which employ 70 percent of the nation’s workforce.That puts at risk Japan’s recovery from the worst postwar recession it is now facing. The $232 billion restaurant industry is crucial to boosting growth as it, together with lodging, creates about 1.3 million new jobs a year, or roughly 17 percent of all the new employment. More than 190 small businesses including 30 restaurant operators have gone bust during the current health crisis.Yet, the government’s slow response in pushing through billions of dollars stuck in paperwork is threatening the same fate for many more firms in urgent need of cash to pay salaries and rents.In contrast, authorities have rapidly pressed ahead with plans to spend nearly $16 billion for a “go-to” campaign to promote tourism, and $1.3 billion to help politically powerful farmers and fishermen promote expensive foodstuffs such as mangoes, tunas and yellowtails. An extra $90 million has also been set aside to promote international flights – when almost all planes are grounded.“We, as well as many others, are running out of money. If the situation is left as is, we will go under one after another. Then, no one will be left to benefit from the tourism campaign,” said Yoshikazu Moriyama, 42.
6 Edinburgh Court, Castle Hill“Ah, the sweet smell of success. There must be big money in flowers these days. A local florist, who prefers not to be named, has reportedly just paid a record price for a house in Townsville – a cool $320,000,” the report read.“Needless to say, the house is up on Townsville’s own “millionaire row” (alias “mortgage hill”), Yarrawonga. Apparently the sale is supposed to be one of Townsville’s best kept secrets.” More than three decades later the property is again expected to create interest, being put on the market for the first time since.But this time the sale is no big secret – the owner is none other than retired businesswoman Lorna Mead of Day Dawn Florist. 6 Edinburgh Court, Castle Hill“We’ve always been content there. It has a wonderful garden and we always had lots of visitors, the house was always full of people,” Ms Mead said.“It’s the kind of house that is comfortable for a family but also a great entertainer.“The reason I’m selling is because my husband Ray passed away two months ago and I’m 74, retired and ready to move on.” 6 Edinburgh Court, Castle HillThe spacious, north-facing, three-bedroom home has returned to the market by listing agent Julie Mahoney from Harcourts Kingsberry. To be auctioned on May 16, the property comes with awe-inspiring views out to Magnetic Island while adjoining bushland reserve. It includes three living areas, a study and a saltwater pool on a 809sq m block. 6 Edinburgh Court, Castle HillMore from news01:21Buyer demand explodes in Townsville’s 2019 flood-affected suburbs12 Sep 202001:21‘Giant surge’ in new home sales lifts Townsville property market10 Sep 2020“I don’t actually remember being contacted by a journalist so imagine our surprise when we saw the article in the paper the next day (after the original sale),” Ms Mead said.“While $320,000 was certainly a lot of money at the time, we didn’t know it was the largest amount paid for a home at Yarrawonga at the time but of course prices started going up from there.“We just liked the house, made an offer and got accepted. In fact, we weren’t even looking for a home and were quite content living at Pallarenda.“What appealed to us were the views and the property had the potential for a wonderful garden which has developed over the years.” Lorna Mead is selling her home atEdinburgh Court, Castle Hill. Picture: Evan MorganNOTHING created more of a stir in the Townsville real estate market than the purchase of 6 Edinburgh Court on Castle Hill almost 32 years ago.It was the time when Yarrawonga established itself as “millionaire row” – a place with homes only the rich and famous could afford. Or so they thought.In May, 1985 an article in the Townsville Daily Bulletin created a buzz when a journalist reported on the sale of the high-end property.
16 Mary St, West End.It also has a media room, outdoor entertaining area, shed and large yard.The house been updated but still retains plenty of character.Ms Mahoney said she was confident Townsville’s property market was improving.“We’ve got cranes in the sky, we’ve got development and we had 23 groups through our open homes last weekend so all the key indicators are there,” she said.“I think people have a lot more confidence to buy now.“October was probably our best month in three years.” 16 Mary St, West EndA WEST End house has sold for the highest price in the suburb in more than a year as confidence in Townsville’s property market returns.Julie Mahoney from Ray White Julie Mahoney sold 16 Mary St, West End, at auction for $580,000 as three registered bidders vied for the property.It was the highest residential, single dwelling sale since September 2017, according to REA when 1B Plant St sold for $630,000. 16 Mary St, West EndMs Mahoney said the Mary St property was bought by a professional couple with children who liked the large block and location.“They liked the suburb and it’s a really good street,” she said. “You have two very big, separate lounge areas and at the back is a studio which provides a work-from-home option.More from news01:21Buyer demand explodes in Townsville’s 2019 flood-affected suburbs12 Sep 202001:21‘Giant surge’ in new home sales lifts Townsville property market10 Sep 2020Ms Mahoney said West End was becoming increasingly popular with buyers.“West End is really popular at the moment and I’m finding a lot of young couples are moving in and it has low insurance because most of the suburb is in a no-flood area,” she said.“It’s so close to the city and contrary to what people believe it’s very breezy, even though people think because it’s tucked under the hill it will be hot.”The four-bedroom, three- bathroom house is on a 1214sq m block with four car accommodation.
admin State budget vs. job creation – January 22, 2015 Hancock County Court News Nov. 3 thorugh Dec. 11 – January 22, 2015 Bio House fire in Winter Harbor – October 27, 2014 Latest Posts Ryan Maddocks of the Ellsworth Eagles dives back to first base as Cam Wentworth of the Bucksport Golden Bucks takes the throw.—HUGH BOWDENBUCKSPORT — A six-run fourth inning lifted the Bucksport Golden Bucks to an 11-6 win over the Ellsworth Eagles in baseball action on Thursday, April 30. Ellsworth jumped out to a 3-0 lead in the first inning on a run-scoring double by Pat Kelley, a single by Mickey Manning and a two-run single by Jordan Carter.The Golden Bucks, who upped their record to 3-1, scored twice in the bottom of the inning when a single by Kyle McGeechan was misplayed in left field, allowing two runners to score.Ellsworth added two more in the top of the second on two walks, a run-scoring groundout by Brad Folmer and an RBI single by Kelley.This is placeholder textThis is placeholder textAgain the Bucks responded, knotting the score at 5-5 in the bottom of the third, taking advantage of three walks by Ellsworth righthander John Carlin, a bunt single by Steve Klenowski and a looping single over shortstop by McGeechan.The roof fell in on the Eagles in the fourth. A single by Ryan Bailey and a walk to Ray Wood brought lefthander Adam Kaspala on in relief of Carlin.But Kaspala walked Tyler French to load the bases and Klenowski contributed a two-run single, driving in the first of six runs that crossed the plate before the inning was over.Klenowski finished with a double and three singles and McGeechan had three singles in Bucksport’s 10-hit attack.Manning and Carter each had three singles for Ellsworth, which lost for the first time against two wins.Righthander Tyler French, who settled down after his shaky start, got the wind for Bucksport with relief help from Klenowski in the seventh innning. For more sports stories, pick up a copy of The Ellsworth American. Latest posts by admin (see all)
LEFT-HANDERS Devon Smith of Windward Islands Volcanoes and Veerasammy Permaul of Guyana Jaguars were the top individual performers in the 2017-18 Digicel 4-Day Championship which ended on Sunday.Smith gathered 1,095 runs at an average of 84.23 to cover himself in personal glory. He became the fourth batsman to score more than 1,000 runs in a single Windies first-class season and establish a new record for the most runs in a single Windies first-class season.It was a remarkable achievement for the veteran left-handed opener, considering he reached the mark in just 10 matches. He earns the Viv Richards Award and a US$1,500 cheque.Permaul collected exactly 50 wickets at 18.90 apiece. It is the second time that the left-arm spinner has finished with the most wickets in a season. He earns the Courtney Walsh Award and a US$1,500 prize.Veerasammy PermaulJaguars’ Anthony Bramble effected 45 dismissals, comprising 42 catches and three stumpings. He was the leading wicketkeeper this season and takes the Deryck Murray Award and a US$1,500 cheque, the same amount that has been secured by Jonathan Carter, who also earned the Clive Lloyd Award for holding 17 catches in the field.Two other individual awards, chosen by the selection panel of Cricket West Indies, have been announced.John Campbell of Jamaica Scorpions has earned the Malcolm Marshall Award and a US$1,500 payday for being the top all-rounder, having accumulated 603 runs at an average of 43.07 and collected 19 wickets at 24.52 apiece.Shermon Lewis of Windward Islands Volcanoes has won the Andy Roberts Award and a US$1,000 cheque for being the most promising fast bowler. He collected 30 wickets at 21.70 apiece in his first full season of the #D4-Day.Champions Guyana Jaguars also pocketed US$36,000, comprising US$15,000 for winning the Championship and US$21,000 for winning seven matches.For winning each match, the teams gained US$3,000. As a result, Barbados Pride and Jamaica Scorpions earned US$9,000, and Leeward Islands Hurricanes, Windward Islands Volcanoes and Trinidad & Tobago Red Force collected US$6,000.
Associated Press May 23, 2020 Spanish Prime Minister Pedro Sánchez says soccer league in Spain will resume on June 8 Share This StoryFacebookTwitteremailPrintLinkedinRedditMADRID (AP) — Spanish Prime Minister Pedro Sánchez says soccer league in Spain will resume on June 8.,Tampa Bay Lightning advance to face Dallas Stars in Stanley Cup finals, beating New York Islanders 2-1 in OT in Game 6
Marek Hamsik set up the opener and came up with a contender for goal of the tournament as Slovakia beat Russia 2-1 in Lille yestersday to claim a first European Championship finals win.Hamsik’s pass released Vladimir Weiss to score in the 32nd minute at the Stade Pierre Mauroy and the Napoli star doubled the lead in style right on the stroke of half-time.Russia pushed in the second half but were left with too much to do, even if Denis Glushakov got one back in the 80th minute to set up a grandstand finale. The result allowed Jan Kozak’s team to bounce back from the 2-1 defeat to Wales with which they started their Euro 2016 campaign and put pressure on their Group B rivals before England take on the Welsh in Lens today.Russia prop up the group with one point from two matches and will surely now need to beat Wales in their final group game to keep their hopes of reaching the last 16 alive.The build-up to this match in far northern France had been overshadowed by hooliganism fears with Russia having been told they would be thrown out of the competition if there was any repeat of the crowd trouble at the end of their draw with England in Marseille.However, there was a much calmer atmosphere inside the stands, while the match was played with the stadium roof closed.Kozak made three changes to the Slovakia team beaten by Wales, including handing a start to Ondrej Duda, the young forward who had come off the bench to net in the opening match.After a slow start Russia grew into the game and their powerful centre-forward Artem Dzyuba, of Zenit St Petersburg, nearly caught out Slovakian ‘keeper Matus Kovacik with a header after good play down the right by Igor Smolnikov.Dzyuba then displayed his strength to set up Fedor Smolov for a low shot that fizzed inches wide of the left post as the half-hour approached, but soon after that Slovakia were in front.Hamsik undid the Russia defence with a superb left-foot pass in behind right-back Igor Smolnikov. Weiss still had work to do though, as he cut back onto his right foot and finished with aplomb past Igor Akinfeev into the far corner.Leonid Slutsky’s side were stunned but there was worse to come for them, and better from Hamsik, as the interval approached.The Russian defence was still organising itself when Weiss played a corner short to Hamsik. Oleg Shatov came across in an attempt to block Hamsik but the 28-year-old turned back onto his right foot and curled a tremendous effort in off the far post.It was arguably the goal of Euro 2016 so far and it had the Slovakians at that end of the ground in raptures.Slutsky changed his two central midfielders at half-time, replacing Roman Neustaedter and Aleksandr Golovin with Glushakov and Pavel Mamaev.It was Glushakov of Spartak Moscow who reduced the arrears in the 80th minute, heading home after Shatov had played a one-two with Roman Shirokov and crossed from the left byline. But Slovakia held on.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram